Psychedelic Use Risks Increase with Mood Stabilizers, Large Doses, Negative Mindset

  • SOURCE ▸
    PUBLISHED
  • April 1, 2023
  • AUTHORS
  • Otto Simonsson, Peter S. Hendricks, Richard Chambers
  • PUBLICATION
  • Journal of Affective Disorders
  • TITLE
  • Psychedelic Use Risks Increase with Mood Stabilizers, Large Doses, Negative Mindset
  • Prevalence and associations of challenging, difficult or distressing experiences using classic psychedelics
  • KEY TAKEAWAY
  • While the majority of individuals who have used classic psychedelics do not report challenging or distressing experiences, factors such as co-use of mood stabilizers, lack of preparation, negative mindset, unsupportive environment, large doses, and major life events prior to use can increase the risk of difficult experiences and potential harm.

Introduction

Classic psychedelics, such as LSD, psilocybin, and mescaline, have garnered scientific interest for their profound effects on perception, cognition, and emotion. These substances can induce a wide range of experiences, from insightful and mystical to challenging and distressing.

Factors Influencing Challenging Experiences

Research suggests that personality traits, like neuroticism, may predispose individuals to more challenging experiences with psychedelics. Individuals with higher levels of neuroticism should approach these substances cautiously to avoid negative reactions.

The Role of Set and Setting

The context in which psychedelics are consumed significantly influences the experience. Uncontrolled settings increase the likelihood of challenging experiences, while structured environments with proper support can mitigate risks. The concept of "set and setting" is crucial in shaping the outcome of a psychedelic experience.

Balancing Risks and Benefits

Despite the potential for challenging experiences, classic psychedelics also offer therapeutic benefits, including long-term positive changes in mental health. Maximizing these benefits while minimizing risks requires careful consideration of individual factors, preparation, and supportive settings.

Conclusion

Classic psychedelics have the potential for both positive therapeutic outcomes and challenging experiences. Awareness, education, and harm reduction practices are essential for promoting safety and maximizing the benefits of these substances.

Stay Informed

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