The resurgence of psychedelic medicines as clinical treatments has sparked significant interest among professionals and the general public alike. Psychedelic-assisted therapy (PAT) shows promising evidence for effectiveness, but there remains a substantial gap in understanding how to utilize PAT safely and effectively within clinical populations. Moreover, the introduction of non-clinical stakeholders brings additional interests and agendas that may not align with clinical objectives. The article by Andrew Penn and Rachel Yehuda published on December 13, 2023, explores the historical context in which psychedelics were initially banned and proposes research questions aimed at bridging these knowledge gaps. The focus is on identifying the necessary research directions to ensure that PAT can be effectively and safely implemented for patients who could benefit from such treatments.