Psilocybin Risks Mitigated by Dose Control, Patient Screening, Supervision

  • SOURCE ▸
    PUBLISHED
  • November 1, 2018
  • AUTHORS
  • Matthew W. Johnson, Roland R. Griffiths, Peter S. Hendricks
  • PUBLICATION
  • Neuropharmacology
  • TITLE
  • Psilocybin Risks Mitigated by Dose Control, Patient Screening, Supervision
  • The abuse potential of medical psilocybin according to the 8 factors of the Controlled Substances Act
  • KEY TAKEAWAY
  • While psilocybin, a psychedelic found in certain mushrooms, has limited reinforcing effects and low abuse potential, it can lead to dangerous behavior in unprepared, unsupervised users and exacerbate mental illness in those predisposed to psychotic disorders; these risks can be mitigated through dose control, patient screening, and supervised sessions in a medical facility.

The Abuse Potential of Medical Psilocybin According to the 8 Factors of the Controlled Substances Act

Introduction

The paper reviews the abuse potential of medically administered psilocybin, following the US Controlled Substances Act's structure. It emphasizes psilocybin's potential for treating psychiatric distress related to cancer and substance use disorders.Abuse Potential of Psilocybin:Psilocybin, a classic psychedelic, has limited reinforcing effects and shows a low scope of use and associated harms compared to other abused drugs. Its medical model mitigates potential harms through controlled dosing, patient screening, and supervised sessions in medical facilities.

Conclusion

The review concludes that psilocybin possesses an appropriate abuse potential for scheduling under the CSA if approved as a medicine. It suggests that scheduling psilocybin no more restrictively than Schedule IV may be appropriate upon approval as a medicine, emphasizing its therapeutic benefits and manageable risk profile.Implications for Organizations:This information is pivotal for organizations focused on psychedelic harm reduction and public safety. It underscores psilocybin's therapeutic potential while highlighting the importance of controlled medical use to mitigate risks.Public Awareness:For public awareness, it's crucial to convey that while psilocybin has shown promise for treating certain psychiatric conditions, its use must be carefully managed to prevent abuse and adverse effects. This underscores the necessity of a regulatory framework that balances medical benefits against potential for misuse.Recommendations:The study's insights into psilocybin's low abuse potential and manageable risks, when used medically, provide a strong argument for re-evaluating its legal status and considering its therapeutic potential more broadly.

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