The study "Harnessing placebo: Lessons from psychedelic science" by Chloé Pronovost-Morgan, Ido Hartogsohn, and Johannes G. Ramaekers (2023) explores the potential of the placebo effect within the context of psychedelic science, focusing on the significant impact that non-drug factors—such as physical, social, and cultural variables—can have on drug effects. These non-drug factors, often referred to as the "set and setting," play a crucial role in shaping the experiences and outcomes of psychedelic use. The authors propose a framework inspired by psychedelic science to better understand and utilize these extra-pharmacological variables in clinical care.This research is particularly relevant for organizations focused on psychedelic harm reduction and safety. The key findings highlight the importance of context and the individual's mindset in influencing the effects of psychedelics. It suggests that beyond the pharmacological action of these substances, the environment in which they are taken and the expectations of the user significantly contribute to the overall experience.For harm reduction practices, this implies that providing a supportive, positive environment and educating users about the potential influences of their mindset and setting can enhance safety and reduce risks. It also opens avenues for leveraging the placebo effect in therapeutic settings, potentially improving outcomes by carefully designing the context in which psychedelics are administered.This summary underscores the significance of the placebo effect in psychedelic experiences and suggests practical applications for harm reduction. By acknowledging and harnessing the power of non-drug factors, harm reduction advocates can better guide users towards safer and more positive psychedelic experiences.For more detailed information and insights from the study, visit the Journal of Psychopharmacology (Oxford, England).