The use of magic mushrooms, primarily sought for their psilocybin content, has been a subject of both cultural and scientific interest due to their psychoactive properties. A comprehensive review aimed at assessing the overall risk associated with magic mushroom consumption concluded that these substances exhibit a low potential for physical and psychological dependence. Moreover, their acute toxicity is considered moderate, while chronic toxicity is low, posing negligible public health and criminal concerns (van Amsterdam, Opperhuizen, & van den Brink, 2011). Notably, the combined use of magic mushrooms and alcohol, along with the setting of consumption, warrants attention. Despite the relatively mild adverse effects reported, the low but unpredictable risk of panic attacks and flashbacks remains a point of concern.From a harm reduction perspective, understanding and addressing the factors that contribute to adverse experiences is crucial. A study examining emergency medical treatment seeking following magic mushroom use found that such incidents are rare and mostly involve psychological symptoms like anxiety and paranoia, often exacerbated by poor "mindset" and "setting" or the concomitant use of other substances. Remarkably, nearly all individuals returned to normalcy within 24 hours, underscoring the transient nature of these adverse effects (Kopra, Ferris, Winstock, Young, & Rucker, 2022).This evidence underscores the relative safety of magic mushrooms when compared to other psychoactive substances, though it also highlights the importance of contextual factors in mitigating risks. Harm reduction strategies focusing on educating users about the importance of a positive mindset, a safe setting, and caution against mixing substances could significantly reduce the incidence of negative experiences. Furthermore, these findings call for a nuanced approach to the legal and health policy frameworks surrounding psychedelic substance use, suggesting that informed and responsible use within supportive environments may minimize harm while allowing individuals to explore the potential benefits of these substances for personal growth, therapy, and spiritual experiences.Understanding the context and content of these discussions is imperative for public safety and awareness, emphasizing the role of education, harm reduction practices, and supportive policy in navigating the complexities of psychedelic substance use.