Psychedelics, substances known for their capacity to alter perception, consciousness, and cognitive processes, have been the subject of increased scientific interest and research. The resurgence of research into these substances has highlighted their potential therapeutic benefits, yet it also underscores a critical gap in our understanding of the typical user profile and the long-term mental health consequences of psychedelic use. A methodological review conducted by P. Johnstad (2020) delves into this issue, emphasizing the need for a nuanced understanding of the psychedelics user population and the consequences of their use.Johnstad's analysis reveals a fragmented research landscape where studies often focus on specific segments of the user population, thereby ignoring the broader diversity of usage patterns and experiences. This segmentation likely connects to different patterns of use, which in turn could lead to varying long-term mental health outcomes. For instance, studies focusing on individuals with problematic usage patterns generally associate psychedelic use with negative mental health outcomes. In contrast, research involving infrequent users often reports positive outcomes. Such divergent findings suggest the existence of distinct subpopulations within the broader psychedelics user community, each with unique experiences and consequences of use.The lack of a reliable model to represent the psychedelics user population hampers the ability of researchers to contextualize their findings and assess their broader applicability. To address this challenge, Johnstad proposes three theoretical models that aim to provide a framework for understanding the diversity within the user population. These models are intended to facilitate the contextualization of research findings, potentially clarifying the current disagreements within the field.For harm reduction practitioners and organizations, these insights underscore the importance of adopting a tailored approach to psychedelic harm reduction. Recognizing the diversity within the psychedelics user population is crucial for developing effective strategies and interventions. By acknowledging and addressing the varied patterns of use and their associated risks, harm reduction efforts can be more accurately directed towards those most in need. Furthermore, this understanding can inform public awareness campaigns, ensuring that safety messages are appropriately nuanced and reach the intended audiences.In summary, the research highlights the complexity of the psychedelics user population and the consequential methodological challenges faced by researchers. It calls for a nuanced approach to harm reduction, one that is informed by a deeper understanding of the diverse experiences and outcomes associated with psychedelic use. Such an approach is not only crucial for minimizing the potential risks and harms but also for maximizing the therapeutic potential of these substances (Johnstad, 2020).