Introduction

Lysergic acid diethylamide (LSD) has seen a resurgence in both recreational use and scientific interest, with potential therapeutic benefits. Despite its potent effects, a study by Kopra et al. (2022) sheds light on the relative safety of LSD in recreational settings.

Key Findings

- A small fraction (1.0%) of past-year LSD users sought emergency medical treatment (EMT), with a per-event risk estimate of 0.2%.

- Factors like younger age, existing mental health conditions, and higher frequency of LSD use were linked to increased EMT seeking.

- Most adverse symptoms were psychological, attributed to inadequate 'setting' and 'mindset' at the time of use.

- Majority recovered within 24 hours, but some reported persistent issues beyond four weeks.

Implications

The study highlights the importance of set and setting in mitigating risks associated with LSD use. In recreational contexts, LSD is relatively safe, with short-lived and psychological adverse reactions. This insight is crucial for harm reduction strategies and patient safety in clinical settings.

Conclusion

These findings are significant for public awareness and safety, informing discussions on psychedelic harm reduction and promoting responsible LSD use. They provide valuable knowledge for individuals and professionals in substance use and mental health fields.